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VECURONIUM BROMIDE
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DOSAGE FORM: Lyophilized Injection, 4mg/vial, 10mg/vial.

BIOLOGICAL SIGNIFICANCE

Vecuronium bromide is a muscle relaxant in the category of non depolarising neuromuscular blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent.

CLINICAL USE

Vecuronium bromide is used to facilitate tracheal intubation and provide neuromuscular blockade in patients undergoing laparoscopic sterilization.

Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation

MODE OF ACTION

Depolarizing neuromuscular blocking agents compete with acetylcholine for the cholinergic receptors of the motor end plate and, like acetylcholine, combine with these receptors to produce depolarization; however, because of their high affinity for the cholinergic receptors and their resistance to acetyl cholinesterase, they produce a more prolonged depolarization than does acetylcholine. This results initially in transient muscle contractions, usually visible as fasciculations, followed by inhibition of neuromuscular transmission. This type of neuromuscular block is not antagonized, and may even be enhanced, by anticholinesterase agents.

With prolonged or repeated use of depolarizing neuromuscular blocking agents, neuromuscular blockade resembling a nondepolarization block may be produced, resulting in prolonged respiratory depression or apnea.

Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents.

STRUCTURE:

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