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MILRINONE LACTATE
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DOSAGE FORM: Liquid Injection , 1mg/vial

BIOLOGICAL SIGNIFICANCE

A new class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines.

CLINICAL USE

Milrinone is indicated for the short-term management of congestive heart failure.

Milrinone has been used primarily in patients concurrently receiving digoxin and diuretics.

MODE OF ACTION

Milrinone is a phosphodiesterase inhibitor that has direct positive inotropic and vasodilatory actions. Milrinone increases cardiac contractility which results in an increase in cardiac output .Milrinone also relaxes both arterial and venous smooth muscle, thereby reducing both preload and after load. These effects are mediated by an increase in cytoplasmic cyclic adenosine monophosphate (cAMP) resulting from phosphodiesterase III inhibition in cardiac and smooth muscle.

STRUCTURE

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