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EPIRUBICIN
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DOSAGE FORM:

BIOLOGICAL SIGNIFICANCE

Epirubicin is a chemotherapy drug that is given as a treatment for many different types of cancer. , Epirubicin acts by intercalating DNA strands. Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage.

CLINICAL USE

Epirubicin is used in the treatment of a variety of cancers including breast, ovarian, stomach and bowel, malignant lymphomas, soft tissue sarcoma, gastric, hepatic, pancreatic and sigma-rectum; head and neck cancer and leukemias.

MODE OF ACTION

One way in which epirubicin works is by binding to the cancer cells’ DNA (the genetic code). This makes the DNA get tangled up and the cancer cell cannot divide or grow. Epirubicin forms a complex with DNA by intercalation of its planar rings between nucleotide base pairs, with consequent inhibition of nucleic acid (DNA and RNA) and protein synthesis.

Such intercalation triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity. Epirubicin also inhibits DNA helicase activity, preventing the enzymatic separation of double-stranded DNA and interfering with replication and transcription.

Epirubicin is also involved in oxidation/reduction reactions by generating cytotoxic free radicals. The antiproliferative and cytotoxic activity of Epirubicin is thought to result from these or other possible mechanisms.

STRUCTURE:

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