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CISPLATIN IP
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DOSAGE FORM: Liquid Injection, 10mg/10ml, 50mg/50ml

BIOLOGICAL SIGNIFICANCE

Cisplatin is a platinum-based chemotherapy drug.

CLINICAL USE

It is most commonly used to treat testicular, bladder, lung, gullet (oesophagus), stomach and ovarian cancers.

MODE OF ACTION

Inside a cell, cisplatin undergoes hydrolysis, producing the highly reactive charged platinum complex [Pt (NH3)2ClH2O] +. This complex coordinates to DNA through the N7 atom of either a guanine or adenine base. Further hydrolysis displaces the remaining chloride ligand, and the platinum can bind to a second nucleotide base. The cisplatin-DNA adduct is recognized by a high mobility group (HMG)-domain protein--among other DNA repair proteins--which binds tightly to the complex. The adduct causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, cisplatin can be thought of as a monkey wrench in the DNA excision repair system

STRUCTURE:

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SPECIFICATIONS
 
Assay NLT 90% - NMT 110%
Identifications Complies to IP
PH 3.5 – 6.5
Related substances Complies to IP
BET NMT 2.0 EU per mg of cisplatin
Sterility Complies to IP
   
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