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CARBOPLATIN
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DOSAGE FORM: Liquid Injection, 150mg/15ml, 450mg/45ml

BIOLOGICAL SIGNIFICANCE

Carboplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer.

CLINICAL USE

Treating mainly ovarian carcinoma, lung, head and neck cancers

MODE OF ACTION

They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

1) Attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA,

2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and

3) the induction of mispairing of the nucleotides leading to mutations.

STRUCTURE:

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