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CHORIONIC GONADOTROPHIN
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DOSAGE FORM: Lyophilized Injection, 2000IU/vial, 5000IU/vial, 10000 IU/vial.

BIOLOGICAL SIGNIFICANCE

Human chorionic gonadotropin (HCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the syncytiotrophoblast (part of the placenta). Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. HCG may have additional functions, for instance it is thought that it affects the immune tolerance of the pregnancy. Early pregnancy testing generally is based on the detection or measurement of HCG. Because HCG is produced also by some kinds of tumor, HCG is an important tumor marker, but it is not known whether this production is a contributing cause or an effect of tumorigenesis.

CLINICAL USE

HCG can be used clinically to induce ovulation in the ovaries as well as testosterone production in the testes. As the most abundant biological source is women who are presently pregnant, some organizations collect urine from gravidae to extract HCG for use in fertility treatment.

It also plays a role in cellular differentiation/proliferation and may activate apoptosis

MODE OF ACTION

HCG interacts with the LHCG receptor and promotes the maintenance of the corpus luteum during the beginning of pregnancy causing it to secrete the hormone progesterone. Progesterone enriches the uterus with a thick lining of blood vessels and capillaries so that it can sustain the growing fetus. Due to its highly negative charge HCG may repel the immune cells of the mother, protecting the fetus during the first trimester. It has also been hypothesized that HCG may be a placental link for the development of local maternal immunotolerance.

SPECIFICATIONS

Assay NLT 80% - NMT 125%
Identification Complies to IP
Water content NMT 5%
PH 6.0 – 8.0 (1% W/V solution)
Pyrogen Complies to IP
Sterility Complies to IP
Abnormal toxicity Complies to IP
   
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